Paul Tisdale's men have not played since December 18, when they thrashed Sheffield Wednesday, keeping his charges fresh for the encounter at St Mary's.
Troy Archibald-Henville returns after missing the 5-1 defeat of the Owls through a one-match suspension.
Tisdale may tinker with his squad with the Grecians one point off the play-offs.
He told thisisdevon.co.uk: "We have got a good core of 17 or 18 players and the 11 who play on Saturday will probably not be the same 11 that play the rest of the season.
"I want the squad to stay together because I think we have got a chance of pushing even further up the table."