Noble had to be stretchered off during the second half of the 1-0 home win over Plymouth last Saturday after falling awkwardly on his ankle and is a major doubt.
Striker John O'Flynn is definitely sidelined as he continues to struggle with the toe injury that kept him out against Argyle.
Veteran defender Rob Edwards is likely to feature in what will be his final game for the club as he is set to retire after the match. He is expected to start on the bench but should make his 180th appearance for City as a substitute.
Midfielder Ryan Harley should start on his final outing for the Grecians. He signed for Swansea on a free in January but was loaned back to Exeter for the remainder of the campaign.
Source: PA
Source: PA